Aspirin

Low dose aspirin treatment has been shown to enhance blood in multiple different organ systems. This may be accomplished by proportionally greater inhibition of vascoconstricting prostaglandins (thromboxane A2) than the vasodilating prostaglandins (prostacyclin). A recent trial from Argentina details a prospective randomized and controlled evaluation of the impact of 100 mg of aspirin on multiple variables including ovarian responsiveness, oocyte number, implantation rates, and pregnancy rates. The authors report dramatic improvements in gonadotropin responsiveness, pregnancy rates, and implantation rates. The patient population was not limited to low responders and thus apply to the general population. This treatment will require evaluation in other centers before definitive conclusions are possible, but it certainly deserves further study. (Source: Textbook of Assisted Reproductive Techniques. Edited by Gardner, Howles, Weissman, and Shoham. Martin Dunitz, 2001)

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